Title |
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China
|
---|---|
Published in |
Virology Journal, April 2012
|
DOI | 10.1186/1743-422x-9-82 |
Pubmed ID | |
Authors |
Yang Yong-lin, Fu Qiang, Zhang Ming-shun, Cai Jie, Ma Gui-ming, Huang Zu-hu, Cai Xu-bing |
Abstract |
Hepatitis B virus (HBV) is still one of the serious infectious risks for the blood transfusion safety in China. One plausible reason is the emergence of the variants in the major antigenic alpha determinant within the major hydrophilic region (MHR) of hepatitis B surface antigen (HBsAg), which have been assumed to evade the immune surveillance and pose a challenge to the disease diagnosis. It is well documented that some commercial ELISA kits could detect the wild-type but not the mutant viruses. The high prevalence of HBV in China also impaired the application of nucleic acid testing (NAT) in the improvement of blood security. Molecular epidemiological study of HBsAg variations in China is still limited. This study was designed to identify the prevalence of mutations in the HBsAg in voluntary blood donors in Nanjing, China. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 80% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Gambia | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 28% |
Researcher | 5 | 13% |
Student > Ph. D. Student | 4 | 10% |
Student > Doctoral Student | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Other | 8 | 20% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 25% |
Medicine and Dentistry | 10 | 25% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Immunology and Microbiology | 3 | 8% |
Nursing and Health Professions | 3 | 8% |
Other | 3 | 8% |
Unknown | 7 | 18% |