Title |
Anti-biofilm Activity as a Health Issue
|
---|---|
Published in |
Frontiers in Microbiology, April 2016
|
DOI | 10.3389/fmicb.2016.00592 |
Pubmed ID | |
Authors |
Sylvie Miquel, Rosyne Lagrafeuille, Bertrand Souweine, Christiane Forestier |
Abstract |
The formation and persistence of surface-attached microbial communities, known as biofilms, are responsible for 75% of human microbial infections (National Institutes of Health). Biofilm lifestyle confers several advantages to the pathogens, notably during the colonization process of medical devices and/or patients' organs. In addition, sessile bacteria have a high tolerance to exogenous stress including anti-infectious agents. Biofilms are highly competitive communities and some microorganisms exhibit anti-biofilm capacities such as bacterial growth inhibition, exclusion or competition, which enable them to acquire advantages and become dominant. The deciphering and control of anti-biofilm properties represent future challenges in human infection control. The aim of this review is to compare and discuss the mechanisms of natural bacterial anti-biofilm strategies/mechanisms recently identified in pathogenic, commensal and probiotic bacteria and the main synthetic strategies used in clinical practice, particularly for catheter-related infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Serbia | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 338 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 63 | 19% |
Student > Master | 33 | 10% |
Student > Bachelor | 33 | 10% |
Researcher | 30 | 9% |
Student > Doctoral Student | 17 | 5% |
Other | 48 | 14% |
Unknown | 116 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 13% |
Immunology and Microbiology | 35 | 10% |
Medicine and Dentistry | 34 | 10% |
Biochemistry, Genetics and Molecular Biology | 34 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 4% |
Other | 45 | 13% |
Unknown | 132 | 39% |