Title |
In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literature
|
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Published in |
Breast Cancer Research, April 2012
|
DOI | 10.1186/bcr3132 |
Pubmed ID | |
Authors |
Jonathan KP Begley, Thomas W Redpath, Patrick J Bolan, Fiona J Gilbert |
Abstract |
An emerging clinical modality called proton magnetic resonance spectroscopy ((1)H-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with (1)H-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. (1)H-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast (1)H-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of (1)H-MRS for breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Austria | 1 | 2% |
Brazil | 1 | 2% |
Egypt | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 17% |
Researcher | 8 | 17% |
Student > Master | 6 | 13% |
Other | 4 | 9% |
Student > Bachelor | 3 | 6% |
Other | 10 | 21% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Engineering | 4 | 9% |
Agricultural and Biological Sciences | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Physics and Astronomy | 2 | 4% |
Other | 4 | 9% |
Unknown | 13 | 28% |