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Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Overview of attention for article published in American Journal of Human Genetics, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 4,518)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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35 Dimensions

Readers on

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89 Mendeley
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2 CiteULike
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Title
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility
Published in
American Journal of Human Genetics, May 2016
DOI 10.1016/j.ajhg.2016.03.008
Pubmed ID
Authors

Hamdi Mbarek, Stacy Steinberg, Dale R. Nyholt, Scott D. Gordon, Michael B. Miller, Allan F. McRae, Jouke Jan Hottenga, Felix R. Day, Gonneke Willemsen, Eco J. de Geus, Gareth E. Davies, Hilary C. Martin, Brenda W. Penninx, Rick Jansen, Kerrie McAloney, Jacqueline M. Vink, Jaakko Kaprio, Robert Plomin, Tim D. Spector, Patrik K. Magnusson, Bruno Reversade, R. Alan Harris, Kjersti Aagaard, Ragnar P. Kristjansson, Isleifur Olafsson, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, William G. Iacono, Cornelis B. Lambalk, Grant W. Montgomery, Matt McGue, Ken K. Ong, John R.B. Perry, Nicholas G. Martin, Hreinn Stefánsson, Kari Stefánsson, Dorret I. Boomsma

Abstract

Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10(-9), and rs17293443 in SMAD3, p = 1.57 × 10(-8)) and replicated (p = 3 × 10(-3) and p = 1.44 × 10(-4), respectively). Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score (PRS) for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland (p = 0.001). A higher PRS was also associated with having children (p = 0.01), greater lifetime parity (p = 0.03), and earlier age at first child (p = 0.02). Allele rs11031006-G was associated with higher serum FSH levels, earlier age at menarche, earlier age at first child, higher lifetime parity, lower PCOS risk, and earlier age at menopause. Conversely, rs17293443-C was associated with later age at last child. We identified robust genetic risk variants for DZ twinning: one near FSHB and a second within SMAD3, the product of which plays an important role in gonadal responsiveness to FSH. These loci contribute to crucial aspects of reproductive capacity and health.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Luxembourg 1 1%
Finland 1 1%
Netherlands 1 1%
Unknown 84 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Researcher 15 17%
Student > Bachelor 10 11%
Professor > Associate Professor 10 11%
Professor 7 8%
Other 29 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 27%
Medicine and Dentistry 15 17%
Biochemistry, Genetics and Molecular Biology 13 15%
Unspecified 13 15%
Psychology 10 11%
Other 14 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 759. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2019.
All research outputs
#6,433
of 12,980,349 outputs
Outputs from American Journal of Human Genetics
#6
of 4,518 outputs
Outputs of similar age
#312
of 263,251 outputs
Outputs of similar age from American Journal of Human Genetics
#2
of 60 outputs
Altmetric has tracked 12,980,349 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,518 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,251 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.