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Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism

Overview of attention for article published in Nutrition & Metabolism, April 2016
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2 tweeters

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16 Mendeley
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Title
Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
Published in
Nutrition & Metabolism, April 2016
DOI 10.1186/s12986-016-0090-1
Pubmed ID
Authors

Ping Zhang, Lulu Li, Zhengxi Bao, Feiruo Huang

Abstract

The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 25%
Researcher 4 25%
Student > Ph. D. Student 3 19%
Lecturer 1 6%
Student > Doctoral Student 1 6%
Other 3 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 44%
Agricultural and Biological Sciences 5 31%
Unspecified 2 13%
Neuroscience 1 6%
Medicine and Dentistry 1 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2016.
All research outputs
#5,499,233
of 7,628,277 outputs
Outputs from Nutrition & Metabolism
#421
of 505 outputs
Outputs of similar age
#171,190
of 266,355 outputs
Outputs of similar age from Nutrition & Metabolism
#14
of 15 outputs
Altmetric has tracked 7,628,277 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.0. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,355 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.