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Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence

Overview of attention for article published in Clinics, November 2019
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Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
Published in
Clinics, November 2019
DOI 10.6061/clinics/2019/e1316
Pubmed ID

Vitor Iglesias Mangolini, Laura Helena Andrade, Francisco Lotufo-Neto, Yuan-Pang Wang


The aim of this study was to review emerging evidence of novel treatments for anxiety disorders. We searched PubMed and EMBASE for evidence-based therapeutic alternatives for anxiety disorders in adults, covering the past five years. Eligible articles were systematic reviews (with or without meta-analysis), which evaluated treatment effectiveness of either nonbiological or biological interventions for anxiety disorders. Retrieved articles were summarized as an overview. We assessed methods, quality of evidence, and risk of bias of the articles. Nineteen systematic reviews provided information on almost 88 thousand participants, distributed across 811 clinical trials. Regarding the interventions, 11 reviews investigated psychological or nonbiological treatments; 5, pharmacological or biological; and 3, more than one type of active intervention. Computer-delivered psychological interventions were helpful for treating anxiety of low-to-moderate intensity, but the therapist-oriented approaches had greater results. Recommendations for regular exercise, mindfulness, yoga, and safety behaviors were applicable to anxiety. Transcranial magnetic stimulation, medication augmentation, and new pharmacological agents (vortioxetine) presented inconclusive benefits in patients with anxiety disorders who presented partial responses or refractoriness to standard treatment. New treatment options for anxiety disorders should only be provided to the community after a thorough examination of their efficacy.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 17%
Student > Master 11 15%
Researcher 8 11%
Student > Doctoral Student 7 10%
Student > Ph. D. Student 4 6%
Other 10 14%
Unknown 20 28%
Readers by discipline Count As %
Medicine and Dentistry 14 19%
Psychology 13 18%
Nursing and Health Professions 9 13%
Neuroscience 3 4%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 7 10%
Unknown 24 33%