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Oxidation of sitosterol and transport of its 7-oxygenated products from different tissues in humans and ApoE knockout mice

Overview of attention for article published in Journal of Steroid Biochemistry & Molecular Biology, April 2016
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Title
Oxidation of sitosterol and transport of its 7-oxygenated products from different tissues in humans and ApoE knockout mice
Published in
Journal of Steroid Biochemistry & Molecular Biology, April 2016
DOI 10.1016/j.jsbmb.2016.04.011
Pubmed ID
Authors

Hans-Frieder Schött, Sabine Baumgartner, Constanze Husche, Alexandra Luister, Silvia Friedrichs, Charlotte M. Miller, Florence O. McCarthy, Jogchum Plat, Ulrich Laufs, Oliver Weingärtner, Dieter Lütjohann

Abstract

The most common phytosterols in the human diet are sitosterol and campesterol, which originate exclusively from plant derived food. These phytosterols are taken up by NPC1L1 transport from the intestine into the enterocytes together with cholesterol and other xenosterols. Phytosterols are selectively pumped back from the enterocytes into the intestinal lumen and on the liver site from hepatocytes into bile by heterodimeric ABCG5/G8 transporters. Like cholesterol, both phytosterols are prone to ring and side chain oxidation. It could be shown that oxyphytosterols, found in atherosclerotic tissue, are most likely of in situ oxidation (Schött et al.; Biochem Biophys Res Commun. 2014 Apr 11;446(3):805-10). However, up to now, the entire mechanism of phytosterol oxidation is not clearly understood. Here, we provide further information about the oxidation of sitosterol and the transport of its oxidation products out of tissue. Our survey includes data of 104 severe aortic stenosis patients that underwent an elective aortic valve cusp replacement. We studied their phytosterol concentrations, as well as absolute and substrate corrected oxyphytosterol levels in plasma and valve cusp tissue. In addition, we also examined phytosterol and oxyphytosterol concentrations in plasma and tissues (from brain and liver) of 10 male ApoE knockout mice. The ratio of 7-oxygenated-sitosterol-to-sitosterol exceeds the ratio for 7-oxygenated-campesterol-to-campesterol in plasma and tissue of both humans and mice. This finding indicates that sitosterol is oxidized to a higher amount than campesterol and that a selective oxidative mechanism might exist which can differentiate between certain phytosterols. Secondly, the concentrations of oxyphytosterols found in plasma and tissue support the idea that oxysitosterols are preferably transported out of individual tissues. Selective oxidation of sitosterol and preferred transport of sitosterol oxidation products out of tissue seem to be a metabolic pathway of forced sitosterol clearance from tissue compartments.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 25%
Student > Ph. D. Student 3 13%
Other 1 4%
Lecturer 1 4%
Lecturer > Senior Lecturer 1 4%
Other 3 13%
Unknown 9 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Agricultural and Biological Sciences 2 8%
Chemistry 2 8%
Neuroscience 1 4%
Other 1 4%
Unknown 11 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2016.
All research outputs
#20,660,501
of 25,386,051 outputs
Outputs from Journal of Steroid Biochemistry & Molecular Biology
#2,467
of 2,989 outputs
Outputs of similar age
#232,294
of 312,034 outputs
Outputs of similar age from Journal of Steroid Biochemistry & Molecular Biology
#28
of 43 outputs
Altmetric has tracked 25,386,051 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,989 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,034 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.