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Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction

Overview of attention for article published in Skeletal Muscle, May 2016
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4 tweeters

Citations

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17 Dimensions

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38 Mendeley
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Title
Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction
Published in
Skeletal Muscle, May 2016
DOI 10.1186/s13395-016-0089-3
Pubmed ID
Authors

Molly H. Jenkins, Sarah S. Alrowaished, Michelle F. Goody, Bryan D. Crawford, Clarissa A. Henry

Abstract

Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle development and function, mechanisms underlying ECM remodeling in vivo remain elusive. One excellent paradigm in which to study ECM remodeling in vivo is morphogenesis of the myotendinous junction (MTJ) during zebrafish skeletal muscle development. During MTJ development, there are dramatic shifts in the primary components comprising the MTJ matrix. One such shift involves the replacement of Fibronectin (Fn)-rich matrix, which is essential for both somite and early muscle development, with laminin-rich matrix essential for normal function of the myotome. Here, we investigate the mechanism underlying this transition. We show that laminin polymerization indirectly promotes Fn downregulation at the MTJ, via a matrix metalloproteinase 11 (Mmp11)-dependent mechanism. Laminin deposition and organization is required for localization of Mmp11 to the MTJ, where Mmp11 is both necessary and sufficient for Fn downregulation in vivo. Furthermore, reduction of residual Mmp11 in laminin mutants promotes a Fn-rich MTJ that partially rescues skeletal muscle architecture. These results identify a mechanism for Fn downregulation at the MTJ, highlight crosstalk between laminin and Fn, and identify a new in vivo function for Mmp11. Taken together, our data demonstrate a novel signaling pathway mediating Fn downregulation. Our data revealing new regulatory mechanisms that guide ECM remodeling during morphogenesis in vivo may inform pathological conditions in which Fn is dysregulated.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 21%
Student > Ph. D. Student 8 21%
Researcher 7 18%
Student > Postgraduate 4 11%
Student > Master 2 5%
Other 4 11%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 32%
Biochemistry, Genetics and Molecular Biology 10 26%
Medicine and Dentistry 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Engineering 2 5%
Other 4 11%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2016.
All research outputs
#8,392,883
of 13,936,448 outputs
Outputs from Skeletal Muscle
#229
of 261 outputs
Outputs of similar age
#132,263
of 261,940 outputs
Outputs of similar age from Skeletal Muscle
#1
of 1 outputs
Altmetric has tracked 13,936,448 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 261 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,940 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them