Title |
Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
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Published in |
Frontiers in Microbiology, May 2016
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DOI | 10.3389/fmicb.2016.00622 |
Pubmed ID | |
Authors |
Ewa Otręebska-Machaj, Jacqueline Chevalier, Jadwiga Handzlik, Ewa Szymańska, Jakub Schabikowski, Gérard Boyer, Jean-Michel Bolla, Katarzyna Kieć-Kononowicz, Jean-Marie Pagès, Sandrine Alibert |
Abstract |
Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically important antibiotic classes out of the cell. Drug pumps are attractive targets to restore the susceptibility toward the expelled antibiotics by impairing their efflux activity. Arylhydantoin derivatives were investigated for their potentiation of activities of selected antibiotics described as efflux substrates in Enterobacter aerogenes expressing or not AcrAB pump. Several compounds increased the bacterial susceptibility toward nalidixic acid, chloramphenicol and sparfloxacin and were further pharmacomodulated to obtain a better activity against the AcrAB producing bacteria. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 21% |
Student > Ph. D. Student | 8 | 17% |
Researcher | 6 | 13% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 5 | 10% |
Unknown | 13 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 15% |
Chemistry | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Medicine and Dentistry | 5 | 10% |
Agricultural and Biological Sciences | 4 | 8% |
Other | 6 | 13% |
Unknown | 14 | 29% |