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Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease

Overview of attention for article published in npj Genomic Medicine, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 105)
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
16 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
15 Mendeley
citeulike
1 CiteULike
Title
Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease
Published in
npj Genomic Medicine, January 2016
DOI 10.1038/npjgenmed.2016.8
Pubmed ID
Authors

Philip C Robinson, Paul J Leo, Jennifer J Pointon, Jessica Harris, Katie Cremin, Linda A Bradbury, Simon Stebbings, Andrew A Harrison, , Emma L Duncan, David M Evans, Paul B Wordsworth, Matthew A Brown, Australian Osteoporosis Genetics Consortium, Eugene McCloskey, John Eisman, Graeme Jones, Geoff Nicholson, Richard Eastell, Philip Sambrook (deceased), Richard Prince, Elaine Dennison, Ian Reid, John Wark, Wellcome Trust Case Control Consortium, Management Committee, Peter Donnelly, Ines Barroso, Jenefer M Blackwell, Elvira Bramon, Juan P Casas, Aiden Corvin, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin NA Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Data and Analysis Group, Chris C A Spencer, Gavin Band, Céline Bellenguez, Colin Freeman, Garrett Hellenthal, Eleni Giannoulatou, Matti Pirinen, Richard Pearson, Amy Strange, Zhan Su, Damjan Vukcevic, DNA, Genotyping, Data QC and Informatics Group, Cordelia Langford, Sarah E Hunt, Sarah Edkins, Rhian Gwilliam, Hannah Blackburn, Suzannah J Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T McCann, Jennifer Liddle, Simon C Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker, Publications Committee, Chris CA Spencer

Abstract

Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting primarily the spine and pelvis. The condition is strongly associated with HLA-B*27 as well as other human leukocyte antigen variants and at least 47 individual non-MHC-associated variants. However, substantial additional heritability remains as yet unexplained. To identify further genetic variants associated with the disease, we undertook an association study of AS in 5,040 patients and 21,133 healthy controls using the Illumina Exomechip microarray. A novel association achieving genome-wide significance was noted at CDKAL1. Suggestive associations were demonstrated with common variants in FAM118A, C7orf72 and FAM114A1 and with a low-frequency variant in PNPLA1. Two of the variants have been previously associated with inflammatory bowel disease (IBD; CDKAL1 and C7orf72). These findings further increase the evidence for the marked similarity of genetic risk factors for IBD and AS, consistent with the two diseases having similar aetiopathogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 27%
Researcher 3 20%
Student > Bachelor 3 20%
Student > Master 1 7%
Lecturer > Senior Lecturer 1 7%
Other 3 20%
Readers by discipline Count As %
Medicine and Dentistry 8 53%
Agricultural and Biological Sciences 3 20%
Unspecified 1 7%
Immunology and Microbiology 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2018.
All research outputs
#1,345,013
of 12,354,606 outputs
Outputs from npj Genomic Medicine
#41
of 105 outputs
Outputs of similar age
#42,036
of 269,023 outputs
Outputs of similar age from npj Genomic Medicine
#1
of 6 outputs
Altmetric has tracked 12,354,606 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 105 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,023 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them