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MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

Overview of attention for article published in PLOS ONE, September 2011
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Mentioned by

patent
1 patent

Citations

dimensions_citation
140 Dimensions

Readers on

mendeley
162 Mendeley
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Title
MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay
Published in
PLOS ONE, September 2011
DOI 10.1371/journal.pone.0024753
Pubmed ID
Authors

Sanne Skovgård Veidal, Morten Asser Karsdal, Efstathios Vassiliadis, Arkadiusz Nawrocki, Martin Røssel Larsen, Quoc Hai Trieu Nguyen, Per Hägglund, Yunyun Luo, Qinlong Zheng, Ben Vainer, Diana Julie Leeming

Abstract

During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 4 2%
Unknown 158 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 20%
Researcher 29 18%
Student > Master 21 13%
Other 14 9%
Student > Bachelor 13 8%
Other 26 16%
Unknown 26 16%
Readers by discipline Count As %
Medicine and Dentistry 37 23%
Agricultural and Biological Sciences 34 21%
Biochemistry, Genetics and Molecular Biology 31 19%
Immunology and Microbiology 8 5%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Other 11 7%
Unknown 35 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2014.
All research outputs
#7,413,489
of 22,664,644 outputs
Outputs from PLOS ONE
#87,969
of 193,509 outputs
Outputs of similar age
#43,824
of 126,336 outputs
Outputs of similar age from PLOS ONE
#1,027
of 2,506 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,336 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,506 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.