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Association of GRP78, HIF-1α and BAG3 Expression with the Severity of Chronic Lymphocytic Leukemia

Overview of attention for article published in Anti-Cancer Agents in Medicinal Chemistry, May 2020
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Title
Association of GRP78, HIF-1α and BAG3 Expression with the Severity of Chronic Lymphocytic Leukemia
Published in
Anti-Cancer Agents in Medicinal Chemistry, May 2020
DOI 10.2174/1871520619666191211101357
Pubmed ID
Authors

Roghayeh Ijabi, Parisa Roozehdar, Reza Afrisham, Hemen Moradi-Sardareh, Saeed Kaviani, Janat Ijabi, Amirhossein Sahebkar

Abstract

Parallel with the progression of Chronic Lymphocytic Leukemia (CLL), the levels of 78KDa Glucose-Regulated Protein (GRP78) and Hypoxia-Inducible Factor 1 alpha (HIF-1α) are increased as they may activate the induction of anti-apoptotic proteins such as BCL2 Associated Athanogene 3 (BAG3). Previous studies have indicated that there is a positive correlation among GRP78, HIF-1α and BAG3. To evaluate the effect of metabolic factors involved in invasive CLL on apoptotic factors. A case-control study was conducted on 77 patients diagnosed with CLL along with 100 healthy individuals. Cell blood count was performed for all participants. According to the Binet's classification, CLL patients were divided into different groups. B cells were isolated from peripheral blood of CLL patients by binding to anti-CD19 beads. The expression of BAG3, GRP78 and HIF-1α genes was analyzed using RT-PCR method. To confirm the results of RT-PCR, western blot analysis was carried out. The results showed that there was a strong association among the expression of BAG3, GRP78 and HIF-1α. The stage of CLL in patients was highly correlated with the expression rate of each gene (p<0.001). Accordingly, the western blot analysis indicated that the concentrations of GRP78 and HIF-1α were significantly higher than the expression of BAG3 considering the stage of CLL. It was shown that increased expression of GRP78 and HIF-1α could result in the elevation of BAG3, as well as the disease progression. Therefore, the role of these metabolic factors might be more pronounced compared with the anti-apoptotic agents to monitor disease progression in CLL patients.

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Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2019.
All research outputs
#13,436,376
of 15,220,159 outputs
Outputs from Anti-Cancer Agents in Medicinal Chemistry
#446
of 673 outputs
Outputs of similar age
#284,994
of 345,056 outputs
Outputs of similar age from Anti-Cancer Agents in Medicinal Chemistry
#5
of 15 outputs
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So far Altmetric has tracked 673 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.