Title |
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus
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Published in |
Journal of Neuroinflammation, May 2012
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DOI | 10.1186/1742-2094-9-87 |
Pubmed ID | |
Authors |
Cristina Pintado, María P Gavilán, Elena Gavilán, Luisa García-Cuervo, Antonia Gutiérrez, Javier Vitorica, Angélica Castaño, Rosa M Ríos, Diego Ruano |
Abstract |
Neuroinflammation and protein accumulation are characteristic hallmarks of both normal aging and age-related neurodegenerative diseases. However, the relationship between these factors in neurodegenerative processes is poorly understood. We have previously shown that proteasome inhibition produced higher neurodegeneration in aged than in young rats, suggesting that other additional age-related events could be involved in neurodegeneration. We evaluated the role of lipopolysaccharide (LPS)-induced neuroinflammation as a potential synergic risk factor for hippocampal neurodegeneration induced by proteasome inhibition. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 2 | 2% |
Netherlands | 1 | 1% |
Switzerland | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 76 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 17% |
Researcher | 14 | 17% |
Student > Master | 13 | 16% |
Student > Bachelor | 11 | 13% |
Professor > Associate Professor | 8 | 10% |
Other | 14 | 17% |
Unknown | 8 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 30% |
Biochemistry, Genetics and Molecular Biology | 14 | 17% |
Neuroscience | 12 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Medicine and Dentistry | 3 | 4% |
Other | 8 | 10% |
Unknown | 13 | 16% |