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Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

Overview of attention for article published in Journal of Neuroinflammation, May 2012
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Title
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus
Published in
Journal of Neuroinflammation, May 2012
DOI 10.1186/1742-2094-9-87
Pubmed ID
Authors

Cristina Pintado, María P Gavilán, Elena Gavilán, Luisa García-Cuervo, Antonia Gutiérrez, Javier Vitorica, Angélica Castaño, Rosa M Ríos, Diego Ruano

Abstract

Neuroinflammation and protein accumulation are characteristic hallmarks of both normal aging and age-related neurodegenerative diseases. However, the relationship between these factors in neurodegenerative processes is poorly understood. We have previously shown that proteasome inhibition produced higher neurodegeneration in aged than in young rats, suggesting that other additional age-related events could be involved in neurodegeneration. We evaluated the role of lipopolysaccharide (LPS)-induced neuroinflammation as a potential synergic risk factor for hippocampal neurodegeneration induced by proteasome inhibition.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 2%
Netherlands 1 1%
Switzerland 1 1%
Spain 1 1%
United States 1 1%
Unknown 76 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 17%
Researcher 14 17%
Student > Master 13 16%
Student > Bachelor 11 13%
Professor > Associate Professor 8 10%
Other 14 17%
Unknown 8 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 30%
Biochemistry, Genetics and Molecular Biology 14 17%
Neuroscience 12 15%
Pharmacology, Toxicology and Pharmaceutical Science 7 9%
Medicine and Dentistry 3 4%
Other 8 10%
Unknown 13 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2012.
All research outputs
#17,489,487
of 25,654,806 outputs
Outputs from Journal of Neuroinflammation
#2,033
of 2,969 outputs
Outputs of similar age
#116,319
of 176,814 outputs
Outputs of similar age from Journal of Neuroinflammation
#26
of 42 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,969 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,814 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.