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In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds

Overview of attention for article published in BMC Complementary and Alternative Medicine, December 2019
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  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Citations

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9 Dimensions

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66 Mendeley
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Title
In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds
Published in
BMC Complementary and Alternative Medicine, December 2019
DOI 10.1186/s12906-019-2776-1
Pubmed ID
Authors

Nur Zahirah Abd Rani, Endang Kumolosasi, Malina Jasamai, Jamia Azdina Jamal, Kok Wai Lam, Khairana Husain

Abstract

Moringa oleifera Lam. is a commonly used plant in herbal medicine and has various reported bioactivities such as antioxidant, antimicrobial, anticancer and antidiabetes. It is rich in nutrients and polyphenols. The plant also has been traditionally used for alleviating allergic conditions. This study was aimed to examine the anti-allergic activity of M. oleifera extracts and its isolated compounds. M. oleifera leaves, seeds and pods were extracted with 80% of ethanol. Individual compounds were isolated using a column chromatographic technique and elucidated based on the nuclear magnetic resonance (NMR) and electrospray ionisation mass spectrometry (ESIMS) spectral data. The anti-allergic activity of the extracts, isolated compounds and ketotifen fumarate as a positive control was evaluated using rat basophilic leukaemia (RBL-2H3) cells for early and late phases of allergic reactions. The early phase was determined based on the inhibition of beta-hexosaminidase and histamine release; while the late phase was based on the inhibition of interleukin (IL-4) and tumour necrosis factor (TNF-α) release. Two new compounds; ethyl-(E)-undec-6-enoate (1) and 3,5,6-trihydroxy-2-(2,3,4,5,6-pentahydroxyphenyl)-4H-chromen-4-one (2) together with six known compounds; quercetin (3), kaempferol (4), β-sitosterol-3-O-glucoside (5), oleic acid (6), glucomoringin (7), 2,3,4-trihydroxybenzaldehyde (8) and stigmasterol (9) were isolated from M. oleifera extracts. All extracts and the isolated compounds inhibited mast cell degranulation by inhibiting beta-hexosaminidase and histamine release, as well as the release of IL-4 and TNF-α at varying levels compared with ketotifen fumarate. The study suggested that M. oleifera and its isolated compounds potentially have an anti-allergic activity by inhibiting both early and late phases of allergic reactions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 12%
Student > Master 7 11%
Other 4 6%
Student > Ph. D. Student 3 5%
Lecturer > Senior Lecturer 2 3%
Other 9 14%
Unknown 33 50%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 9%
Engineering 4 6%
Medicine and Dentistry 3 5%
Agricultural and Biological Sciences 2 3%
Other 8 12%
Unknown 35 53%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2021.
All research outputs
#13,325,956
of 21,353,399 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,440
of 3,016 outputs
Outputs of similar age
#207,576
of 378,624 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#127
of 336 outputs
Altmetric has tracked 21,353,399 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,016 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 378,624 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 336 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.