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Structural Analyses of the Slm1-PH Domain Demonstrate Ligand Binding in the Non-Canonical Site

Overview of attention for article published in PLOS ONE, May 2012
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Title
Structural Analyses of the Slm1-PH Domain Demonstrate Ligand Binding in the Non-Canonical Site
Published in
PLOS ONE, May 2012
DOI 10.1371/journal.pone.0036526
Pubmed ID
Authors

Kanchan Anand, Kenji Maeda, Anne-Claude Gavin

Abstract

Pleckstrin homology (PH) domains are common membrane-targeting modules and their best characterized ligands are a set of important signaling lipids that include phosphatidylinositol phosphates (PtdInsPs). PH domains recognize PtdInsPs through two distinct mechanisms that use different binding pockets on opposite sides of the β-strands 1 and 2: i) a canonical binding site delimited by the β1-β2 and β3-β4loops and ii) a non-canonical binding site bordered by the β1-β2 and β5-β6loops. The PH domain-containing protein Slm1 from budding yeast Saccharomyces cerevisiae is required for actin cytoskeleton polarization and cell growth. We recently reported that this PH domain binds PtdInsPs and phosphorylated sphingolipids in a cooperative manner.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 34%
Student > Master 7 20%
Researcher 4 11%
Student > Bachelor 3 9%
Professor 2 6%
Other 3 9%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 49%
Biochemistry, Genetics and Molecular Biology 8 23%
Chemistry 3 9%
Unspecified 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 6%
Unknown 3 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2012.
All research outputs
#18,305,773
of 22,664,644 outputs
Outputs from PLOS ONE
#153,775
of 193,509 outputs
Outputs of similar age
#126,211
of 163,497 outputs
Outputs of similar age from PLOS ONE
#2,898
of 3,708 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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