Title |
A multicentre randomised controlled trial evaluating lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea in older people admitted to hospital: the PLACIDE study protocol
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Published in |
BMC Infectious Diseases, May 2012
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DOI | 10.1186/1471-2334-12-108 |
Pubmed ID | |
Authors |
Stephen J Allen, Kathie Wareham, Caroline Bradley, Wyn Harris, Anjan Dhar, Helga Brown, Alwyn Foden, Way Yee Cheung, Michael B Gravenor, Sue Plummer, Ceri J Phillips, Dietrich Mack |
Abstract |
Antibiotic associated diarrhoea complicates 5-39% of courses of antibiotic treatment. Major risk factors are increased age and admission to hospital. Of particular importance is C. difficile associated diarrhoea which occurs in about 4% of antibiotic courses and may result in severe illness, death and high healthcare costs. The emergence of the more virulent 027 strain of C. difficile has further heightened concerns. Probiotics may prevent antibiotic associated diarrhoea by several mechanisms including colonization resistance through maintaining a healthy gut flora. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
Iran, Islamic Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 132 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 16% |
Researcher | 19 | 14% |
Other | 15 | 11% |
Student > Ph. D. Student | 13 | 9% |
Student > Bachelor | 13 | 9% |
Other | 27 | 19% |
Unknown | 30 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 55 | 40% |
Agricultural and Biological Sciences | 13 | 9% |
Nursing and Health Professions | 10 | 7% |
Immunology and Microbiology | 4 | 3% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Other | 16 | 12% |
Unknown | 37 | 27% |