Pearson residuals work well to normalize UMI data, as originally suggested by @satijalab: https://t.co/7A21KSdP8n Our prior work on Analytic Pearson residuals comes to a similar conclusion: https://t.co/bdkc68AMY8 The key assumption is that UMI counts ~
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scTransform https://t.co/BnMZ1ZSGCQ
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An important publication focusing on this question is the sctransform paper written by Hafemeister & Satija (from the Seurat team) in 2019: https://t.co/ppv3tvyIwz. They proposed using Pearson residuals derived from regularized negative binomial regres
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RT @Sciwheel: Another Trending Article from December! This one here presents a statistical approach for the normalization and variance stab…