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Identification of New Agonists and Antagonists of the Insect Odorant Receptor Co-Receptor Subunit

Overview of attention for article published in PLOS ONE, May 2012
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Title
Identification of New Agonists and Antagonists of the Insect Odorant Receptor Co-Receptor Subunit
Published in
PLOS ONE, May 2012
DOI 10.1371/journal.pone.0036784
Pubmed ID
Authors

Sisi Chen, Charles W. Luetje

Abstract

Insects detect attractive and aversive chemicals using several families of chemosensory receptors, including the OR family of olfactory receptors, making these receptors appealing targets for the control of insects. Insect ORs are odorant-gated ion channels, comprised of at least one common subunit (the odorant receptor co-receptor subunit, Orco) and at least one variable odorant specificity subunit. Each of the many ORs of an insect species is activated or inhibited by an unique set of odorants that interact with the variable odorant specificity subunits, making the development of OR directed insect control agents complex and laborious. However, several N-,2-substituted triazolothioacetamide compounds (VUAA1, VU0450667 and VU0183254) were recently shown to act directly on the highly conserved Orco subunit, suggesting that broadly active compounds can be developed. We have explored the chemical space around the VUAA1 structure in order to identify new Orco ligands.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Japan 1 2%
Portugal 1 2%
Unknown 55 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 24%
Researcher 13 22%
Student > Ph. D. Student 11 19%
Student > Doctoral Student 2 3%
Student > Bachelor 2 3%
Other 8 14%
Unknown 8 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 48%
Neuroscience 5 9%
Biochemistry, Genetics and Molecular Biology 4 7%
Environmental Science 2 3%
Chemistry 2 3%
Other 6 10%
Unknown 11 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2012.
All research outputs
#20,972,772
of 25,759,158 outputs
Outputs from PLOS ONE
#184,549
of 224,475 outputs
Outputs of similar age
#138,624
of 176,730 outputs
Outputs of similar age from PLOS ONE
#3,004
of 3,807 outputs
Altmetric has tracked 25,759,158 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 224,475 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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We're also able to compare this research output to 3,807 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.