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Diagnosis of placental malaria in poorly fixed and processed placental tissue

Overview of attention for article published in Malaria Journal, May 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

Mentioned by

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3 tweeters
facebook
2 Facebook pages

Citations

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3 Dimensions

Readers on

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32 Mendeley
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Title
Diagnosis of placental malaria in poorly fixed and processed placental tissue
Published in
Malaria Journal, May 2016
DOI 10.1186/s12936-016-1314-6
Pubmed ID
Authors

Yunhao Liu, Jennifer B. Griffin, Atis Muehlenbachs, Stephen J. Rogerson, Anya J. Bailis, Rajni Sharma, David J. Sullivan, Antoinette K. Tshefu, Sarah H. Landis, Jean-Marie M. Kabongo, Steve M. Taylor, Steven R. Meshnick

Abstract

Placental histopathology has been considered the gold standard for diagnosis of malaria during pregnancy. However, in under-resourced areas placental tissue is often improperly fixed and processed; the resulting formalin pigment is difficult to distinguish from malaria pigment. This study examines two alternative diagnostic methods: polymerase chain reaction (PCR) and a novel immunohistochemistry (IHC)-based method using an antibody against histidine-rich protein 2 (HRP2). Placental histopathology from 151 pregnant women in Kinshasa was assessed by two blinded microscopists and compared with peripheral blood PCR and IHC for HRP2. The Cohen's kappa coefficients were calculated to assess the test agreement. The sensitivity and specificity of individual tests were calculated using PCR or IHC as the reference standard as well as latent class analysis (LCA). PCR and IHC correlated fairly well. The correlation between the two blinded microscopists was poor, as there was widespread formalin pigment. Using LCA, all of the tests had high specificities. The most sensitive test was IHC (67.7 %), with PCR as second-best (56.1 %). PCR and/or IHC are suitable diagnostics when the presence of formalin pigment substantially compromises placental histopathology.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 28%
Student > Master 8 25%
Student > Ph. D. Student 3 9%
Other 2 6%
Researcher 2 6%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 11 34%
Immunology and Microbiology 4 13%
Nursing and Health Professions 4 13%
Agricultural and Biological Sciences 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 9%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2019.
All research outputs
#7,581,478
of 14,079,291 outputs
Outputs from Malaria Journal
#2,413
of 4,064 outputs
Outputs of similar age
#109,392
of 263,148 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 14,079,291 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,064 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them