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Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function

Overview of attention for article published in Cilia, January 2016
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34 Mendeley
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Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function
Published in
Cilia, January 2016
DOI 10.1186/s13630-016-0036-2
Pubmed ID

Marshall, Ryan A, Osborn, Daniel P S


Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium. Although these two organelles are closely associated, they have specific roles to complete for successful cellular development. Appropriate development and function of the BB are fundamental for cilia function. Indeed, there are a growing number of human genetic diseases affecting ciliary development, known collectively as the ciliopathies. Accumulating evidence suggests that BBs establish cell polarity, direct ciliogenesis, and provide docking sites for proteins required within the ciliary axoneme. Major contributions to our knowledge of BB structure and function have been provided by studies in flagellated or ciliated unicellular eukaryotic organisms, specifically Tetrahymena and Chlamydomonas. Reproducing these and other findings in vertebrates has required animal in vivo models. Zebrafish have fast become one of the primary organisms of choice for modeling vertebrate functional genetics. Rapid ex-utero development, proficient egg laying, ease of genetic manipulation, and affordability make zebrafish an attractive vertebrate research tool. Furthermore, zebrafish share over 80 % of disease causing genes with humans. In this article, we discuss the merits of using zebrafish to study BB functional genetics, review current knowledge of zebrafish BB ultrastructure and mechanisms of function, and consider the outlook for future zebrafish-based BB studies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 32%
Student > Bachelor 7 21%
Student > Ph. D. Student 7 21%
Student > Master 4 12%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 1 3%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 50%
Agricultural and Biological Sciences 11 32%
Neuroscience 3 9%
Medicine and Dentistry 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%
Unknown 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2016.
All research outputs
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Outputs from Cilia
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Outputs of similar age
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Outputs of similar age from Cilia
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Altmetric has tracked 9,238,399 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 71 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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