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Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function

Overview of attention for article published in Cilia, January 2016
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1 tweeter

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Title
Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function
Published in
Cilia, January 2016
DOI 10.1186/s13630-016-0036-2
Pubmed ID
Authors

Marshall, Ryan A, Osborn, Daniel P S

Abstract

Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium. Although these two organelles are closely associated, they have specific roles to complete for successful cellular development. Appropriate development and function of the BB are fundamental for cilia function. Indeed, there are a growing number of human genetic diseases affecting ciliary development, known collectively as the ciliopathies. Accumulating evidence suggests that BBs establish cell polarity, direct ciliogenesis, and provide docking sites for proteins required within the ciliary axoneme. Major contributions to our knowledge of BB structure and function have been provided by studies in flagellated or ciliated unicellular eukaryotic organisms, specifically Tetrahymena and Chlamydomonas. Reproducing these and other findings in vertebrates has required animal in vivo models. Zebrafish have fast become one of the primary organisms of choice for modeling vertebrate functional genetics. Rapid ex-utero development, proficient egg laying, ease of genetic manipulation, and affordability make zebrafish an attractive vertebrate research tool. Furthermore, zebrafish share over 80 % of disease causing genes with humans. In this article, we discuss the merits of using zebrafish to study BB functional genetics, review current knowledge of zebrafish BB ultrastructure and mechanisms of function, and consider the outlook for future zebrafish-based BB studies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 34%
Student > Bachelor 7 24%
Student > Ph. D. Student 4 14%
Student > Master 3 10%
Student > Doctoral Student 2 7%
Other 3 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 48%
Agricultural and Biological Sciences 10 34%
Neuroscience 3 10%
Unspecified 1 3%
Medicine and Dentistry 1 3%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2016.
All research outputs
#7,040,825
of 9,238,399 outputs
Outputs from Cilia
#53
of 71 outputs
Outputs of similar age
#193,537
of 275,613 outputs
Outputs of similar age from Cilia
#5
of 7 outputs
Altmetric has tracked 9,238,399 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 71 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,613 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.