Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains

RT @boris_ctcf: Actually, in 2015 GB Fig.S11, ChIP-Seq regions w/ at least 2 constrained CTCF motifs (named "2xCTS") were shown to be enric…

Actually, in 2015 GB Fig.S11, ChIP-Seq regions w/ at least 2 constrained CTCF motifs (named "2xCTS") were shown to be enriched at the anchors of 3D TAD-like ChIA-PET loops bound by CTCF+BORIS heteromers in CTCFL positive K562 cells but by CTCF+CTCF homomer

In addition, in a bioRxiv preprint posted 3 years ago by Odom & Flicek at https://t.co/4CVt37nz1w, clustered but not single CTCF binding sites were suggested to be an 'evolutionary mechanism to maintain TAD boundaries' published soon in Genome Biol too

Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains #genome https://t.co/1rdQ4ps1iy