Title |
Feasibility study of first-line chemotherapy using Pemetrexed and Bevacizumab for advanced or recurrent nonsquamous non-small cell lung cancer in elderly patients: TORG1015
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Published in |
BMC Cancer, May 2016
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DOI | 10.1186/s12885-016-2338-6 |
Pubmed ID | |
Authors |
Toshiyuki Kozuki, Naoyuki Nogami, Hiromoto Kitajima, Shunichiro Iwasawa, Emiko Sakaida, Yuichi Takiguchi, Satoshi Ikeda, Masahiro Yoshida, Terufumi Kato, Shingo Miyamoto, Kentaro Sakamaki, Tetsu Shinkai, Koshiro Watanabe |
Abstract |
The addition of bevacizumab to cytotoxic agents prolongs survival in patients with nonsquamous non-small cell lung cancer (NSCLC). To date, there is no evidence to suggest that treatment with a cytotoxic agent plus bevacizumab is more effective than a cytotoxic agent alone for nonsquamous NSCLC in elderly patients. We conducted a feasibility study of pemetrexed plus bevacizumab as a first-line treatment for advanced or recurrent nonsquamous NSCLC in elderly patients. Major eligibility and exclusion criteria included: chemotherapy-naive status; non-fitness for bolus combination chemotherapy; stage III/IV or relapsed nonsquamous NSCLC; age ≥70; performance status 0-1; absence of brain metastasis; and no history of hemoptysis and thoracic irradiation. Pemetrexed (500 mg/m(2)) and bevacizumab (15 mg/kg) were administered intravenously on day 1, and repeated every 3 weeks thereafter. The primary endpoint was safety, and the secondary endpoints were objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and the percentage of patients who completed ≥3 cycles. From October 2010 to April 2012, a total of 12 patients were enrolled. No dose-limiting toxicity or treatment-related deaths were observed. Three patients achieved PR, and the ORR was 25 %. The median PFS and OS were 5.4 months (95 % CI 1.1-8.8 months) and 13.6 months (95 % CI 5.3-15.6 months), respectively. Seven of 12 patients (58 %) received ≥3 cycles. Pemetrexed plus bevacizumab in the treatment of elderly patients with nonsquamous NSCLC was well tolerated and shows promise as first-line treatment. UMIN Clinical Trial Registry; UMIN000004263 . Registered on 25 September, 2010. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 22% |
Lecturer | 3 | 17% |
Other | 3 | 17% |
Student > Ph. D. Student | 3 | 17% |
Student > Master | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 44% |
Nursing and Health Professions | 3 | 17% |
Agricultural and Biological Sciences | 1 | 6% |
Unknown | 6 | 33% |