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Role of tartrate-resistant acid phosphatase (TRAP) in long bone development

Overview of attention for article published in Mechanisms of Development, July 2012
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Title
Role of tartrate-resistant acid phosphatase (TRAP) in long bone development
Published in
Mechanisms of Development, July 2012
DOI 10.1016/j.mod.2012.04.003
Pubmed ID
Authors

Michael J.F. Blumer, Barbara Hausott, Christoph Schwarzer, Alison R. Hayman, Judith Stempel, Helga Fritsch

Abstract

Tartrate resistant acid phosphatase (TRAP) was shown to be critical for skeleton development, and TRAP deficiency leads to a reduced resorptive activity during endochondral ossification resulting in an osteopetrotic phenotype and shortened long bones in adult mice. A proper longitudinal growth depends on a timely, well-coordinated vascularization and formation of the secondary ossification center (SOC) of the long bones epiphysis. Our results demonstrate that TRAP is not essential for the formation of the epiphyseal vascular network. Therefore, in wild type (Wt) controls as well as TRAP deficient (TRAP(-/-)) mutants vascularised cartilage canals are present from postnatal day (P) five. However, in the epiphysis of the TRAP(-/-) mice cartilage mineralization, formation of the marrow cavity and the SOC occur prematurely compared with the controls. In the mutant mice the entire growth plate is widened due to an expansion of the hypertrophic zone. This is not seen in younger animals but first detected at week (W) three and during further development. Moreover, an enhanced number of thickened trabeculae, indicative of the osteopetrotic phenotype, are observed in the metaphysis beginning with W three. Epiphyseal excavation was proposed as an important function of TRAP, and we examined whether TRAP deficiency affects this process. We therefore evaluated the marrow cavity volume (MCV) and the epiphyseal volume (EV) and computed the MCV to EV ratio (MCV/EV). We investigated developmental stages until W 12. Our results indicate that both epiphyseal excavation and establishment of the SOC are hardly impaired in the knockouts. Furthermore, no differences in the morphology of the epiphyseal bone trabeculae and remodeling of the articular cartilage layers are noted between Wt and TRAP(-/-) mice. We conclude that in long bones, TRAP is critical for the development of the growth plate and the metaphysis but apparently not for the epiphyseal vascularization, excavation, and establishment of the SOC.

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Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Unknown 66 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 28%
Student > Bachelor 13 19%
Researcher 7 10%
Student > Master 6 9%
Professor > Associate Professor 5 7%
Other 10 15%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 27%
Medicine and Dentistry 17 25%
Biochemistry, Genetics and Molecular Biology 8 12%
Engineering 4 6%
Immunology and Microbiology 2 3%
Other 9 13%
Unknown 9 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2012.
All research outputs
#9,787,828
of 12,249,897 outputs
Outputs from Mechanisms of Development
#823
of 963 outputs
Outputs of similar age
#81,555
of 114,389 outputs
Outputs of similar age from Mechanisms of Development
#1
of 1 outputs
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