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The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3′ UTR

Overview of attention for article published in BMC Genomics, May 2012
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Title
The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3′ UTR
Published in
BMC Genomics, May 2012
DOI 10.1186/1471-2164-13-182
Pubmed ID
Authors

Marta Iwanaszko, Allan R Brasier, Marek Kimmel

Abstract

The NF-κB family plays a prominent role in the innate immune response, cell cycle activation or cell apoptosis. Upon stimulation by pathogen-associated patterns, such as viral RNA a kinase cascade is activated, which strips the NF-κB of its inhibitor IκBα molecule and allows it to translocate into the nucleus. Once in the nucleus, it activates transcription of approximately 90 genes whose kinetics of expression differ relative to when NF-κB translocates into the nucleus, referred to as Early, Middle and Late genes. It is not obvious what mechanism is responsible for segregation of the genes' timing of transcriptional response.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 8%
Germany 1 4%
Unknown 23 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 42%
Student > Ph. D. Student 5 19%
Student > Bachelor 2 8%
Student > Master 1 4%
Professor 1 4%
Other 0 0%
Unknown 6 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 31%
Biochemistry, Genetics and Molecular Biology 7 27%
Mathematics 3 12%
Unknown 8 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2012.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from BMC Genomics
#7,120
of 11,244 outputs
Outputs of similar age
#115,838
of 176,567 outputs
Outputs of similar age from BMC Genomics
#70
of 130 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,567 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.