Title |
Spatiotemporal Regulation of Hsp90–Ligand Complex Leads to Immune Activation
|
---|---|
Published in |
Frontiers in immunology, May 2016
|
DOI | 10.3389/fimmu.2016.00201 |
Pubmed ID | |
Authors |
Yasuaki Tamura, Akihiro Yoneda, Norio Takei, Kaori Sawada |
Abstract |
Although heat shock proteins (HSPs) primarily play a pivotal role in the maintenance of cellular homeostasis while reducing extracellular as well as intracellular stresses, their role in immunologically relevant scenarios, including activation of innate immunity as danger signals, antitumor immunity, and autoimmune diseases, is now gaining much attention. The most prominent feature of HSPs is that they function both in their own and as an HSP-ligand complex. We here show as a unique feature of extracellular HSPs that they target chaperoned molecules into a particular endosomal compartment of dendritic cells, thereby inducing innate and adaptive immune responses via spatiotemporal regulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 20% |
United Kingdom | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 23% |
Student > Ph. D. Student | 2 | 15% |
Professor | 2 | 15% |
Unspecified | 1 | 8% |
Other | 1 | 8% |
Other | 2 | 15% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 31% |
Agricultural and Biological Sciences | 2 | 15% |
Unspecified | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |