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Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline

Overview of attention for article published in Molecular Cell, July 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
2 blogs
twitter
1 tweeter
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
334 Dimensions

Readers on

mendeley
312 Mendeley
citeulike
3 CiteULike
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Title
Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline
Published in
Molecular Cell, July 2008
DOI 10.1016/j.molcel.2008.06.003
Pubmed ID
Authors

Partha P. Das, Marloes P. Bagijn, Leonard D. Goldstein, Julie R. Woolford, Nicolas J. Lehrbach, Alexandra Sapetschnig, Heeran R. Buhecha, Michael J. Gilchrist, Kevin L. Howe, Rory Stark, Nik Matthews, Eugene Berezikov, René F. Ketting, Simon Tavaré, Eric A. Miska

Abstract

The Piwi proteins of the Argonaute superfamily are required for normal germline development in Drosophila, zebrafish, and mice and associate with 24-30 nucleotide RNAs termed piRNAs. We identify a class of 21 nucleotide RNAs, previously named 21U-RNAs, as the piRNAs of C. elegans. Piwi and piRNA expression is restricted to the male and female germline and independent of many proteins in other small-RNA pathways, including DCR-1. We show that Piwi is specifically required to silence Tc3, but not other Tc/mariner DNA transposons. Tc3 excision rates in the germline are increased at least 100-fold in piwi mutants as compared to wild-type. We find no evidence for a Ping-Pong model for piRNA amplification in C. elegans. Instead, we demonstrate that Piwi acts upstream of an endogenous siRNA pathway in Tc3 silencing. These data might suggest a link between piRNA and siRNA function.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 3%
United Kingdom 4 1%
Germany 3 <1%
France 3 <1%
Mexico 2 <1%
Brazil 1 <1%
Finland 1 <1%
Australia 1 <1%
Taiwan 1 <1%
Other 3 <1%
Unknown 284 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 76 24%
Researcher 68 22%
Student > Master 37 12%
Student > Bachelor 32 10%
Professor > Associate Professor 19 6%
Other 53 17%
Unknown 27 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 185 59%
Biochemistry, Genetics and Molecular Biology 78 25%
Neuroscience 4 1%
Computer Science 4 1%
Engineering 3 <1%
Other 9 3%
Unknown 29 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2019.
All research outputs
#1,741,766
of 20,704,010 outputs
Outputs from Molecular Cell
#1,723
of 6,763 outputs
Outputs of similar age
#10,794
of 141,269 outputs
Outputs of similar age from Molecular Cell
#13
of 84 outputs
Altmetric has tracked 20,704,010 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,763 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,269 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.