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Faculty of 1000 evaluation for Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters.

Overview of attention for article published in ADS, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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100 Dimensions

Readers on

mendeley
292 Mendeley
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1 CiteULike
Title
Faculty of 1000 evaluation for Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters.
Published in
ADS, February 2017
DOI 10.1038/nchem.2519
Pubmed ID
Authors

Babu, M Madan, Weatheritt, Robert

Abstract

Membraneless organelles are cellular compartments made from drops of liquid protein inside a cell. These compartments assemble via the phase separation of disordered regions of proteins in response to changes in the cellular environment and the cell cycle. Here we demonstrate that the solvent environment within the interior of these cellular bodies behaves more like an organic solvent than like water. One of the most-stable biological structures known, the DNA double helix, can be melted once inside the liquid droplet, and simultaneously structures formed from regulatory single-stranded nucleic acids are stabilized. Moreover, proteins are shown to have a wide range of absorption or exclusion from these bodies, and can act as importers for otherwise-excluded nucleic acids, which suggests the existence of a protein-mediated trafficking system. A common strategy in organic chemistry is to utilize different solvents to influence the behaviour of molecules and reactions. These results reveal that cells have also evolved this capability by exploiting the interiors of membraneless organelles.

Twitter Demographics

The data shown below were collected from the profiles of 39 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 3%
United Kingdom 1 <1%
Israel 1 <1%
Netherlands 1 <1%
Taiwan 1 <1%
Japan 1 <1%
Bangladesh 1 <1%
Unknown 278 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 83 28%
Researcher 63 22%
Student > Master 33 11%
Student > Bachelor 28 10%
Student > Doctoral Student 18 6%
Other 47 16%
Unknown 20 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 106 36%
Agricultural and Biological Sciences 61 21%
Chemistry 44 15%
Physics and Astronomy 13 4%
Chemical Engineering 10 3%
Other 24 8%
Unknown 34 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2019.
All research outputs
#407,792
of 14,565,799 outputs
Outputs from ADS
#164
of 27,061 outputs
Outputs of similar age
#12,335
of 265,084 outputs
Outputs of similar age from ADS
#4
of 298 outputs
Altmetric has tracked 14,565,799 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,061 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 298 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.