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Taming tosyl azide: the development of a scalable continuous diazo transfer process

Overview of attention for article published in Organic and Biomolecular Chemistry, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

blogs
1 blog
wikipedia
1 Wikipedia page

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
47 Mendeley
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Title
Taming tosyl azide: the development of a scalable continuous diazo transfer process
Published in
Organic and Biomolecular Chemistry, January 2016
DOI 10.1039/c6ob00246c
Pubmed ID
Authors

Benjamin J. Deadman, Rosella M. O'Mahony, Denis Lynch, Daniel C. Crowley, Stuart G. Collins, Anita R. Maguire

Abstract

Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a 'one pot' batch procedure using shelf stable, readily available reagents. For large scale diazo transfer reactions tosyl azide was generated and used in a telescoped flow process, to mitigate the risks associated with handling potentially explosive reagents on scale. The in situ formed tosyl azide was used to rapidly perform diazo transfer to a range of acceptors, including β-ketoesters, β-ketoamides, malonate esters and β-ketosulfones. An effective in-line quench of sulfonyl azides was also developed, whereby a sacrificial acceptor molecule ensured complete consumption of any residual hazardous diazo transfer reagent. The telescoped diazo transfer process with in-line quenching was used to safely prepare over 21 g of an α-diazocarbonyl in >98% purity without any column chromatography.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Ireland 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 34%
Researcher 7 15%
Student > Bachelor 4 9%
Student > Master 4 9%
Professor 1 2%
Other 3 6%
Unknown 12 26%
Readers by discipline Count As %
Chemistry 28 60%
Chemical Engineering 2 4%
Agricultural and Biological Sciences 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Materials Science 1 2%
Other 1 2%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2020.
All research outputs
#3,145,518
of 19,206,351 outputs
Outputs from Organic and Biomolecular Chemistry
#487
of 5,173 outputs
Outputs of similar age
#54,276
of 275,308 outputs
Outputs of similar age from Organic and Biomolecular Chemistry
#5
of 59 outputs
Altmetric has tracked 19,206,351 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,173 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.