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Hypothalamic‐pituitary‐adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia

Overview of attention for article published in Cochrane database of systematic reviews, May 2012
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Title
Hypothalamic‐pituitary‐adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia
Published in
Cochrane database of systematic reviews, May 2012
DOI 10.1002/14651858.cd008727.pub2
Pubmed ID
Authors

Gordijn MS, Gemke RJ, van Dalen EC, Rotteveel J, Kaspers GJ, Gordijn, Maartje S, Gemke, Reinoud JBJ, van Dalen, Elvira C, Rotteveel, Joost, Kaspers, Gertjan JL, Gemke, Reinoud Jbj, Kaspers, Gertjan Jl

Abstract

Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses may cause suppression of the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis suppression resulting in reduced cortisol response may cause an impaired stress response and an inadequate host defence against infections, which remains a cause of morbidity and death. The exact occurrence and duration of HPA axis suppression after glucocorticoid therapy for childhood ALL are unclear.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Bachelor 8 16%
Student > Master 8 16%
Researcher 6 12%
Other 4 8%
Other 9 18%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 25 50%
Psychology 7 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Agricultural and Biological Sciences 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 6 12%
Unknown 6 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#14,144,226
of 22,665,794 outputs
Outputs from Cochrane database of systematic reviews
#10,371
of 12,296 outputs
Outputs of similar age
#96,162
of 163,698 outputs
Outputs of similar age from Cochrane database of systematic reviews
#138
of 178 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,296 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,698 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.