Title |
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
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Published in |
BMC Genomics, May 2012
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DOI | 10.1186/1471-2164-13-199 |
Pubmed ID | |
Authors |
Himanshu Joshi, Silje H Nord, Arnoldo Frigessi, Anne-Lise Børresen-Dale, Vessela N Kristensen |
Abstract |
The human genome contains a large amount of cis-regulatory DNA elements responsible for directing both spatial and temporal gene-expression patterns. Previous studies have shown that based on their mRNA expression breast tumors could be divided into five subgroups (Luminal A, Luminal B, Basal, ErbB2(+) and Normal-like), each with a distinct molecular portrait. Whole genome gene expression analysis of independent sets of breast tumors reveals repeatedly the robustness of this classification. Furthermore, breast tumors carrying a TP53 mutation show a distinct gene expression profile, which is in strong association to the distinct molecular portraits. The mRNA expression of 552 genes, which varied considerably among the different tumors, but little between two samples of the same tumor, has been shown to be sufficient to separate these tumor subgroups. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Norway | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 5% |
United States | 2 | 5% |
Denmark | 1 | 2% |
Norway | 1 | 2% |
Unknown | 35 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 27% |
Student > Ph. D. Student | 11 | 27% |
Other | 3 | 7% |
Professor > Associate Professor | 3 | 7% |
Student > Bachelor | 2 | 5% |
Other | 3 | 7% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 39% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Computer Science | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Mathematics | 2 | 5% |
Other | 3 | 7% |
Unknown | 9 | 22% |