Title |
Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats
|
---|---|
Published in |
The Journal of Physiological Sciences, February 2020
|
DOI | 10.1186/s12576-020-00735-4 |
Pubmed ID | |
Authors |
Joo Hyun Shin, Yu Fan, Do-Hee Kim, Han Byeol Jang, Suchan Chang, Yeonhee Ryu, Jong Han Bae, Sanghag Lee, Bong Hyo Lee, Scott C. Steffensen, Chae Ha Yang, Hee Young Kim |
Abstract |
While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat model of immobilization-induced hypertension (IMH) and the mediation of endogenous opioid systems in its effect. Cutaneous neurogenic spots were found mostly in the forelimb. Electrical and mechanical acupuncture of Neuro-Sps increased 22-kHz ultrasonic vocalizations (USVs), c-Fos expression and cell excitability in the midbrain and synergistically alleviated the development of hypertension following immobilization stress, which was prevented by administration of the opioid antagonist naloxone into the rostral ventrolateral medulla (rVLM). These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Philippines | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 14% |
Researcher | 2 | 14% |
Student > Bachelor | 1 | 7% |
Other | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 0 | 0% |
Unknown | 7 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 2 | 14% |
Medicine and Dentistry | 2 | 14% |
Neuroscience | 1 | 7% |
Unknown | 9 | 64% |