↓ Skip to main content

Antimicrobial susceptibility of hospital acquired Stenotrophomonas maltophilia isolate biofilms

Overview of attention for article published in Brazilian Journal of Infectious Diseases, July 2016
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
41 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Antimicrobial susceptibility of hospital acquired Stenotrophomonas maltophilia isolate biofilms
Published in
Brazilian Journal of Infectious Diseases, July 2016
DOI 10.1016/j.bjid.2016.04.002
Pubmed ID
Authors

Erlin Sun, Gehong Liang, Lining Wang, Wenjie Wei, Mingde Lei, Shiduo Song, Ruifa Han, Yubao Wang, Wei Qi

Abstract

We sought to characterize the antibiotic susceptibility of strains of Stenotrophomonas maltophilia (SMA) isolated from clinical samples, and the role of SMA biofilm in antibiotic resistance. Fifty-one clinical SMA isolates were obtained from patients with nosocomial infection in the surgical wards and ICUs of six general hospitals in Tianjin, China. In vitro models of SMA biofilms were established and confirmed by scanning electron microscopy (SEM) and fluorescence microscopy (FSM) with silver staining. The minimal inhibitory concentrations (MIC) and biofilm inhibitory concentrations (BIC) of commonly used antibiotics were determined. 47 of 51 strains were resistant to three or more antibiotics. 42 of 51 strains formed SMA biofilms in vitro. SMA biofilm formation greatly reduced sensitivity to most tested antibiotics, but not to levofloxacin (LEV). However, in the presence of erythromycin (ERY) SEM revealed that LEV inhibited SMA biofilm formation. Factorial ANOVA revealed that erythromycin (ERY) enhanced susceptibility to LEV, cefoperazone/sulbactam (SCF), and piperacillin (PIP) (p<0.05), and an ΔE model revealed that LEV and ERY acted synergistically in biofilms, suggesting specific use of combined macrolide therapy may represent an effective treatment for SMA infection. Antibiotics could act synergistically to combat the protection conferred to clinical isolates of SMA by biofilms. Macrolide antibiotics may be effective where used in combination.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 15%
Researcher 4 10%
Student > Master 4 10%
Student > Ph. D. Student 3 7%
Other 2 5%
Other 4 10%
Unknown 18 44%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 10%
Medicine and Dentistry 3 7%
Chemistry 3 7%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 2 5%
Other 6 15%
Unknown 20 49%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2016.
All research outputs
#14,006,862
of 15,884,384 outputs
Outputs from Brazilian Journal of Infectious Diseases
#369
of 486 outputs
Outputs of similar age
#221,073
of 267,062 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#13
of 14 outputs
Altmetric has tracked 15,884,384 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 486 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,062 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.