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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Rab5 is necessary for the biogenesis of the endolysosomal system in vivo
|
|---|---|
| Published in |
Nature, May 2012
|
| DOI | 10.1038/nature11133 |
| Pubmed ID | |
| Authors |
Anja Zeigerer, Jerome Gilleron, Roman L. Bogorad, Giovanni Marsico, Hidenori Nonaka, Sarah Seifert, Hila Epstein-Barash, Satya Kuchimanchi, Chang Geng Peng, Vera M. Ruda, Perla Del Conte-Zerial, Jan G. Hengstler, Yannis Kalaidzidis, Victor Koteliansky, Marino Zerial |
| Abstract |
An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrating down all three Rab5 isoforms in adult mouse liver using state-of-the-art RNA interference technology. Unexpectedly, the endocytic system was resilient to depletion of Rab5 and collapsed only when Rab5 decreased to a critical level. Loss of Rab5 below this threshold caused a marked reduction in the number of early endosomes, late endosomes and lysosomes, associated with a block of low-density lipoprotein endocytosis. Loss of endosomes caused failure to deliver apical proteins to the bile canaliculi, suggesting a requirement for polarized cargo sorting. Our results demonstrate for the first time, to our knowledge, the role of Rab5 as an endosome organizer in vivo and reveal the resilience mechanisms of the endocytic system. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| Chile | 1 | 25% |
| France | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 441 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 8 | 2% |
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| Hungary | 1 | <1% |
| Norway | 1 | <1% |
| India | 1 | <1% |
| Australia | 1 | <1% |
| Italy | 1 | <1% |
| China | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 417 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 112 | 25% |
| Researcher | 98 | 22% |
| Student > Master | 43 | 10% |
| Student > Bachelor | 41 | 9% |
| Student > Doctoral Student | 21 | 5% |
| Other | 65 | 15% |
| Unknown | 61 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 176 | 40% |
| Biochemistry, Genetics and Molecular Biology | 90 | 20% |
| Medicine and Dentistry | 30 | 7% |
| Neuroscience | 23 | 5% |
| Engineering | 12 | 3% |
| Other | 45 | 10% |
| Unknown | 65 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2022.
All research outputs
#1,698,211
of 23,578,176 outputs
Outputs from Nature
#38,926
of 92,699 outputs
Outputs of similar age
#10,413
of 165,687 outputs
Outputs of similar age from Nature
#559
of 981 outputs
Altmetric has tracked 23,578,176 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,699 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,687 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 981 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.