Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

My intuition that non-linear effects add little beyond linear effects comes in part from this paper we published a few years back on utility of incorporating GxG and GxE terms in prediction models: https://t.co/qCwNkVg6nl 5/

Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN

Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN

Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN