Title |
Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
|
---|---|
Published in |
bioRxiv, February 2020
|
DOI | 10.1101/2020.02.07.939207 |
Pubmed ID | |
Authors |
Matthew C. Wong, Sara J. Javornik Cregeen, Nadim J. Ajami, Joseph F. Petrosino |
Abstract |
A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019. |
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Country | Count | As % |
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Israel | 3 | 2% |
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Ireland | 2 | 1% |
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Other | 19 | 13% |
Unknown | 73 | 49% |
Demographic breakdown
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Members of the public | 107 | 72% |
Scientists | 33 | 22% |
Science communicators (journalists, bloggers, editors) | 5 | 3% |
Practitioners (doctors, other healthcare professionals) | 2 | 1% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
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Unknown | 364 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 59 | 16% |
Researcher | 53 | 15% |
Student > Bachelor | 44 | 12% |
Student > Ph. D. Student | 32 | 9% |
Other | 21 | 6% |
Other | 58 | 16% |
Unknown | 97 | 27% |
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Immunology and Microbiology | 16 | 4% |
Veterinary Science and Veterinary Medicine | 12 | 3% |
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