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X Demographics
Mendeley readers
Attention Score in Context
| Title |
α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
|
|---|---|
| Published in |
Journal of Neuroinflammation, May 2012
|
| DOI | 10.1186/1742-2094-9-98 |
| Pubmed ID | |
| Authors |
Yuan Liu, Jun Hu, Jie Wu, Chenlei Zhu, Yujian Hui, Yaping Han, Zuhu Huang, Kevin Ellsworth, Weimin Fan |
| Abstract |
Although evidence suggests that the prevalence of Parkinson's disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying the anti-inflammatory potential of cholinergic agonists in immune cells, including astrocytes, and inhibition of astrocyte activation has been proposed as a novel strategy for the treatment of neurodegenerative disorders such as PD. The objective of the present study was to determine whether nicotine-induced neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model occurs via α7-nAChR-mediated inhibition of astrocytes. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Japan | 1 | 1% |
| Mexico | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 80 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 21% |
| Researcher | 11 | 13% |
| Other | 9 | 11% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 7 | 8% |
| Other | 17 | 20% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 22% |
| Medicine and Dentistry | 11 | 13% |
| Agricultural and Biological Sciences | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 20 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2017.
All research outputs
#14,726,101
of 22,665,794 outputs
Outputs from Journal of Neuroinflammation
#1,637
of 2,605 outputs
Outputs of similar age
#101,175
of 164,339 outputs
Outputs of similar age from Journal of Neuroinflammation
#36
of 55 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,339 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.