You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0037559 |
| Pubmed ID | |
| Authors |
Jianwei Liu, Ning Sun, Marc A. Bruce, Joseph C. Wu, Manish J. Butte |
| Abstract |
We describe a method using atomic force microscopy (AFM) to quantify the mechanobiological properties of pluripotent, stem cell-derived cardiomyocytes, including contraction force, rate, duration, and cellular elasticity. We measured beats from cardiomyocytes derived from induced pluripotent stem cells of healthy subjects and those with dilated cardiomyopathy, and from embryonic stem cell lines. We found that our AFM method could quantitate beat forces of single cells and clusters of cardiomyocytes. We demonstrate the dose-responsive, inotropic effect of norepinephrine and beta-adrenergic blockade of metoprolol. Cardiomyocytes derived from subjects with dilated cardiomyopathy showed decreased force and decreased cellular elasticity compared to controls. This AFM-based method can serve as a screening tool for the development of cardiac-active pharmacological agents, or as a platform for studying cardiomyocyte biology. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 251 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| France | 1 | <1% |
| Ireland | 1 | <1% |
| Hungary | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Russia | 1 | <1% |
| China | 1 | <1% |
| Unknown | 239 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 28% |
| Researcher | 44 | 18% |
| Student > Master | 27 | 11% |
| Student > Doctoral Student | 17 | 7% |
| Student > Bachelor | 17 | 7% |
| Other | 37 | 15% |
| Unknown | 38 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 50 | 20% |
| Agricultural and Biological Sciences | 47 | 19% |
| Biochemistry, Genetics and Molecular Biology | 32 | 13% |
| Medicine and Dentistry | 19 | 8% |
| Physics and Astronomy | 15 | 6% |
| Other | 38 | 15% |
| Unknown | 50 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2021.
All research outputs
#6,750,519
of 22,665,794 outputs
Outputs from PLOS ONE
#79,359
of 193,511 outputs
Outputs of similar age
#47,928
of 163,862 outputs
Outputs of similar age from PLOS ONE
#1,297
of 3,845 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 193,511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3,845 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.