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Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

Overview of attention for article published in BMC Complementary and Alternative Medicine, May 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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30 Dimensions

Readers on

mendeley
51 Mendeley
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Title
Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress
Published in
BMC Complementary and Alternative Medicine, May 2012
DOI 10.1186/1472-6882-12-61
Pubmed ID
Authors

Christoph Klingelhoeffer, Ulrike Kämmerer, Monika Koospal, Bettina Mühling, Manuela Schneider, Michaela Kapp, Alexander Kübler, Christoph-Thomas Germer, Christoph Otto

Abstract

Ascorbic acid demonstrates a cytotoxic effect by generating hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative cell stress. A panel of eleven human cancer cell lines, glioblastoma and carcinoma, were exposed to serial dilutions of ascorbic acid (5-100 mmol/L). The purpose of this study was to analyse the impact of catalase, an important hydrogen peroxide-detoxifying enzyme, on the resistance of cancer cells to ascorbic acid mediated oxidative stress.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 2%
Portugal 1 2%
Denmark 1 2%
Unknown 48 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Student > Bachelor 10 20%
Student > Master 7 14%
Professor > Associate Professor 4 8%
Student > Doctoral Student 3 6%
Other 10 20%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Agricultural and Biological Sciences 12 24%
Biochemistry, Genetics and Molecular Biology 6 12%
Chemistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 7 14%
Unknown 7 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2017.
All research outputs
#6,184,351
of 11,732,910 outputs
Outputs from BMC Complementary and Alternative Medicine
#875
of 2,426 outputs
Outputs of similar age
#48,697
of 109,250 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#38
of 99 outputs
Altmetric has tracked 11,732,910 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,426 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,250 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.