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A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization.

Overview of attention for article published in Journal of General Virology, May 2011
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Title
A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization.
Published in
Journal of General Virology, May 2011
DOI 10.1099/vir.0.032177-0
Pubmed ID
Authors

Glauser DL, Kratz AS, Gillet L, Stevenson PG, D. L. Glauser, A.-S. Kratz, L. Gillet, P. G. Stevenson

Abstract

Glycoprotein B (gB) is a conserved, essential component of gammaherpes virions and so potentially vulnerable to neutralization. However, few good gB-specific neutralizing antibodies have been identified. Here, we show that murid herpesvirus 4 is strongly neutralized by mAbs that recognize an epitope close to one of the gB fusion loops. Antibody binding did not stop gB interacting with its cellular ligands or initiating its fusion-associated conformation change, but did stop gB resolving stably to its post-fusion form, and so blocked membrane fusion to leave virions stranded in late endosomes. The conservation of gB makes this mechanism a possible general route to gammaherpesvirus neutralization.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 45%
Professor 2 18%
Researcher 2 18%
Student > Bachelor 1 9%
Student > Postgraduate 1 9%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 45%
Immunology and Microbiology 3 27%
Veterinary Science and Veterinary Medicine 1 9%
Social Sciences 1 9%
Medicine and Dentistry 1 9%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2012.
All research outputs
#3,320,297
of 4,681,522 outputs
Outputs from Journal of General Virology
#839
of 1,071 outputs
Outputs of similar age
#49,155
of 76,449 outputs
Outputs of similar age from Journal of General Virology
#6
of 11 outputs
Altmetric has tracked 4,681,522 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,071 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,449 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.