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Salivary IgA antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis.

Overview of attention for article published in Immunobiology, June 2012
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Title
Salivary IgA antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis.
Published in
Immunobiology, June 2012
DOI 10.1016/j.imbio.2012.04.011
Pubmed ID
Authors

Svärd A, Kastbom A, Sommarin Y, Skogh T

Abstract

Circulating IgG anti-cyclic citrullinated peptide antibodies (CCP) are highly specific for rheumatoid arthritis (RA) and prognostic of poor outcome. Serum IgA anti-CCP occurs in a subset of IgG-positive cases and relates to still more aggressive disease. Mucosal IgA-class antibodies, however, are generally associated with anti-inflammatory actions and systemic tolerance induction. In the present study, unstimulated salivary samples from 63 patients with established RA and 20 healthy persons were analysed by enzyme-linked immunoassay for the presence of IgA anti-CCP antibodies. To ensure antigen specificity, IgA-reactivity with the corresponding uncitrullinated antigen, cyclic arginine peptide (CAP), was analysed and anti-CCP/anti-CAP ratios calculated. Retrospective data regarding disease activity and radiological outcome were achieved via medical records. Salivary IgA anti-CCP was found in 14/63 (22%) patients and one (5%) control (positive test=anti-CCP/anti-CAP ratio>1.5). Salivary IgA reactivity was dose-dependently inhibited by pre-incubation with soluble CCP to a degree strongly correlating with anti-CCP/anti-CAP ratio. In salivary IgA anti-CCP positive patients, joint erosions within 6 years of diagnosis was significantly lower (p=0.043), and at the time for diagnosis there was a trend towards lower erythrocyte sedimentation rate (p=0.071) and C-reactive protein (p=0.085). Contrasting to circulating IgG and IgA anti-CCP, our results imply that salivary IgA antibodies may be associated with a less severe outcome of RA. Hypothetically, this relates to an anti-inflammatory and protective immunomodulating role of secretory IgA-class autoantibodies against citrullinated antigens presented at mucosal surfaces.

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 39%
Researcher 3 17%
Student > Bachelor 2 11%
Student > Master 2 11%
Student > Postgraduate 2 11%
Other 2 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 39%
Medicine and Dentistry 7 39%
Sports and Recreations 2 11%
Biochemistry, Genetics and Molecular Biology 1 6%
Immunology and Microbiology 1 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2012.
All research outputs
#2,898,470
of 3,631,865 outputs
Outputs from Immunobiology
#206
of 256 outputs
Outputs of similar age
#53,021
of 73,025 outputs
Outputs of similar age from Immunobiology
#8
of 9 outputs
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