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A Historical Overview of Natural Products in Drug Discovery

Overview of attention for article published in Metabolites, April 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 456)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
4 news outlets
twitter
15 tweeters
facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
390 Dimensions

Readers on

mendeley
1473 Mendeley
Title
A Historical Overview of Natural Products in Drug Discovery
Published in
Metabolites, April 2012
DOI 10.3390/metabo2020303
Pubmed ID
Authors

Daniel A. Dias, Sylvia Urban, Ute Roessner

Abstract

Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,473 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 6 <1%
Mexico 5 <1%
Germany 4 <1%
India 4 <1%
United Kingdom 3 <1%
Chile 3 <1%
Malaysia 3 <1%
Nigeria 3 <1%
United States 2 <1%
Other 15 1%
Unknown 1425 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 332 23%
Student > Master 314 21%
Student > Bachelor 266 18%
Researcher 137 9%
Unspecified 135 9%
Other 272 18%
Unknown 17 1%
Readers by discipline Count As %
Chemistry 472 32%
Agricultural and Biological Sciences 313 21%
Unspecified 195 13%
Biochemistry, Genetics and Molecular Biology 187 13%
Pharmacology, Toxicology and Pharmaceutical Science 119 8%
Other 170 12%
Unknown 17 1%

Attention Score in Context

This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2019.
All research outputs
#348,658
of 13,253,522 outputs
Outputs from Metabolites
#3
of 456 outputs
Outputs of similar age
#2,439
of 121,142 outputs
Outputs of similar age from Metabolites
#1
of 1 outputs
Altmetric has tracked 13,253,522 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them