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The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Overview of attention for article published in International Journal of Nanomedicine, May 2016
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2 tweeters

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Title
The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity
Published in
International Journal of Nanomedicine, May 2016
DOI 10.2147/ijn.s94089
Pubmed ID
Authors

Mohammed Mehanna, Nazik Elgindy, Salma Mohyeldin

Abstract

This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent-antisolvent volume ratio on its controlled nanocrystallization has been evaluated. NSs were characterized by transmission electron microscopy, particle size and zeta potential analysis, solubility, and dissolution profiles. The compatibility between RIF and the stabilizer was investigated via Fourier transform infrared spectroscopy and the differential scanning calorimetry techniques. The shelf-life stability of the RIF NS was assessed within a period of 3 months at different storage temperatures. Cell cytotoxicity was evaluated using 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on lung epithelial cells. Polyvinyl alcohol at 0.4% w/v, 1:15 methanol to deionized water volume ratio and 30-minutes sonication were the optimal parameters for RIF NS preparation. Nanocrystals were obtained with a nanometeric particle size (101 nm) and a negative zeta potential (-26 mV). NS exhibited a 50-fold enhancement in RIF solubility and 97% of RIF was dissolved after 10 minutes. The RIF NS was stable at 4±0.5°C with no significant change in particle size or zeta potential. The MTT cytotoxicity assay of RIF NS demonstrated a good safety profile and reduction in cell cytotoxicity with half maximal inhibitory concentration values of 0.5 and 0.8 mg/mL for free RIF and RIF NS, respectively. A novel RIF NS could be followed as an approach for enhancing RIF physicochemical characteristics with a prominence of a safer and better drug delivery.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Student > Bachelor 5 19%
Student > Ph. D. Student 4 15%
Professor > Associate Professor 2 8%
Professor 1 4%
Other 3 12%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 6 23%
Pharmacology, Toxicology and Pharmaceutical Science 5 19%
Chemistry 2 8%
Nursing and Health Professions 1 4%
Agricultural and Biological Sciences 1 4%
Other 3 12%
Unknown 8 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2016.
All research outputs
#4,003,370
of 7,722,452 outputs
Outputs from International Journal of Nanomedicine
#981
of 1,742 outputs
Outputs of similar age
#145,847
of 268,593 outputs
Outputs of similar age from International Journal of Nanomedicine
#88
of 120 outputs
Altmetric has tracked 7,722,452 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,742 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,593 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.