Title |
MicroRNAs and hepatitis C virus: Toward the end of miR-122 supremacy
|
---|---|
Published in |
Virology Journal, June 2012
|
DOI | 10.1186/1743-422x-9-109 |
Pubmed ID | |
Authors |
Thomas Walter Hoffmann, Duverlie Gilles, Bengrine Abderrahmane |
Abstract |
The most common etiologic agents causing chronic hepatitis are hepatitis C and B viruses (HCV and HBV, respectively). Chronic infection caused by HCV is considered one of the major causative agents of liver cirrhosis and hepatocellular carcinoma worldwide. In combination with the increasing rate of new HCV infections, the lack of a current vaccine and/or an effective treatment for this virus continues to be a major public health challenge. The development of new treatments requires a better understanding of the virus and its interaction with the different components of the host cell. MicroRNAs (miRNAs) are small non-coding RNAs functioning as negative regulators of gene expression and represent an interesting lead to study HCV infection and to identify new therapeutic targets. Until now, microRNA-122 (miR-122) and its implication in HCV infection have been the focus of different published studies and reviews. Here we will review recent advances in the relationship between HCV infection and miRNAs, showing that some of them emerge in publications as challengers against the supremacy of miR-122. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Japan | 1 | 1% |
Netherlands | 1 | 1% |
Germany | 1 | 1% |
Unknown | 72 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 23% |
Student > Master | 13 | 17% |
Student > Ph. D. Student | 12 | 16% |
Professor > Associate Professor | 9 | 12% |
Student > Doctoral Student | 8 | 10% |
Other | 15 | 19% |
Unknown | 2 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 40% |
Medicine and Dentistry | 14 | 18% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Immunology and Microbiology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 4 | 5% |
Unknown | 5 | 6% |