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Mendeley readers
Attention Score in Context
| Title |
Host Genes Related to Paneth Cells and Xenobiotic Metabolism Are Associated with Shifts in Human Ileum-Associated Microbial Composition
|
|---|---|
| Published in |
PLOS ONE, June 2012
|
| DOI | 10.1371/journal.pone.0030044 |
| Pubmed ID | |
| Authors |
Tianyi Zhang, Robert A. DeSimone, Xiangmin Jiao, F. James Rohlf, Wei Zhu, Qing Qing Gong, Steven R. Hunt, Themistocles Dassopoulos, Rodney D. Newberry, Erica Sodergren, George Weinstock, Charles E. Robertson, Daniel N. Frank, Ellen Li |
| Abstract |
The aim of this study was to integrate human clinical, genotype, mRNA microarray and 16 S rRNA sequence data collected on 84 subjects with ileal Crohn's disease, ulcerative colitis or control patients without inflammatory bowel diseases in order to interrogate how host-microbial interactions are perturbed in inflammatory bowel diseases (IBD). Ex-vivo ileal mucosal biopsies were collected from the disease unaffected proximal margin of the ileum resected from patients who were undergoing initial intestinal surgery. Both RNA and DNA were extracted from the mucosal biopsy samples. Patients were genotyped for the three major NOD2 variants (Leufs1007, R702W, and G908R) and the ATG16L1T300A variant. Whole human genome mRNA expression profiles were generated using Agilent microarrays. Microbial composition profiles were determined by 454 pyrosequencing of the V3-V5 hypervariable region of the bacterial 16 S rRNA gene. The results of permutation based multivariate analysis of variance and covariance (MANCOVA) support the hypothesis that host mucosal Paneth cell and xenobiotic metabolism genes play an important role in host microbial interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 8% |
| Canada | 3 | 3% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Thailand | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 91 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 28% |
| Student > Ph. D. Student | 20 | 18% |
| Other | 9 | 8% |
| Student > Master | 9 | 8% |
| Professor > Associate Professor | 7 | 6% |
| Other | 26 | 24% |
| Unknown | 8 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 48% |
| Medicine and Dentistry | 21 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Immunology and Microbiology | 5 | 5% |
| Computer Science | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 13 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2020.
All research outputs
#2,444,482
of 22,668,244 outputs
Outputs from PLOS ONE
#31,280
of 193,511 outputs
Outputs of similar age
#16,612
of 167,239 outputs
Outputs of similar age from PLOS ONE
#530
of 3,847 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,239 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 3,847 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.