↓ Skip to main content

Zinc-Finger Antiviral Protein Inhibits XMRV Infection

Overview of attention for article published in PLOS ONE, June 2012
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
66 X users
facebook
3 Facebook pages

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
35 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Zinc-Finger Antiviral Protein Inhibits XMRV Infection
Published in
PLOS ONE, June 2012
DOI 10.1371/journal.pone.0039159
Pubmed ID
Authors

Xinlu Wang, Fan Tu, Yiping Zhu, Guangxia Gao

Abstract

The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV), HIV-1, and certain alphaviruses and filoviruses. ZAP binds to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. The common features of ZAP-responsive RNA sequences remain elusive and thus whether a virus is susceptible to ZAP can only be determined experimentally. Xenotropic murine leukemia virus-related virus (XMRV) is a recently identified γ-retrovirus that was originally thought to be involved in prostate cancer and chronic fatigue syndrome but recently proved to be a laboratory artefact. Nonetheless, XMRV as a new retrovirus has been extensively studied. Since XMRV and MoMLV share only 67.9% sequence identity in the 3'UTRs, which is the target sequence of ZAP in MoMLV, whether XMRV is susceptible to ZAP remains to be determined.

X Demographics

X Demographics

The data shown below were collected from the profiles of 66 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Doctoral Student 6 17%
Researcher 6 17%
Professor 3 9%
Professor > Associate Professor 2 6%
Other 4 11%
Unknown 8 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 29%
Biochemistry, Genetics and Molecular Biology 6 17%
Medicine and Dentistry 4 11%
Immunology and Microbiology 4 11%
Nursing and Health Professions 1 3%
Other 2 6%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2024.
All research outputs
#1,084,040
of 25,877,363 outputs
Outputs from PLOS ONE
#13,812
of 225,708 outputs
Outputs of similar age
#5,580
of 180,324 outputs
Outputs of similar age from PLOS ONE
#193
of 3,861 outputs
Altmetric has tracked 25,877,363 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 225,708 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 3,861 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.