Title |
Cushing’s disease
|
---|---|
Published in |
Orphanet Journal of Rare Diseases, June 2012
|
DOI | 10.1186/1750-1172-7-41 |
Pubmed ID | |
Authors |
Frederic Castinetti, Isabelle Morange, Bernard Conte-Devolx, Thierry Brue |
Abstract |
Cushing's disease, or pituitary ACTH dependent Cushing's syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood pressure, variable levels of hirsutism. Diagnosis is frequently difficult, and requires a strict algorithm. First-line treatment is based on transsphenoidal surgery, which cures 80% of ACTH-secreting microadenomas. The rate of remission is lower in macroadenomas. Other therapeutic modalities including anticortisolic drugs, radiation techniques or bilateral adrenalectomy will thus be necessary to avoid long-term risks (metabolic syndrome, osteoporosis, cardiovascular disease) of hypercortisolism. This review summarizes potential pathophysiological mechanisms, diagnostic approaches, and therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Mexico | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Bangladesh | 1 | <1% |
Australia | 1 | <1% |
Unknown | 154 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 42 | 27% |
Student > Master | 17 | 11% |
Researcher | 12 | 8% |
Student > Doctoral Student | 11 | 7% |
Student > Postgraduate | 11 | 7% |
Other | 15 | 10% |
Unknown | 49 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 38% |
Agricultural and Biological Sciences | 15 | 10% |
Biochemistry, Genetics and Molecular Biology | 14 | 9% |
Nursing and Health Professions | 6 | 4% |
Neuroscience | 5 | 3% |
Other | 8 | 5% |
Unknown | 50 | 32% |