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Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients

Overview of attention for article published in Journal of Neuroscience, June 2012
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Title
Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients
Published in
Journal of Neuroscience, June 2012
DOI 10.1523/jneurosci.0750-12.2012
Pubmed ID
Authors

Timothy L. Hanson, Andrew M. Fuller, Mikhail A. Lebedev, Dennis A. Turner, Miguel A. L. Nicolelis, Hanson TL, Fuller AM, Lebedev MA, Turner DA, Nicolelis MA, T. L. Hanson, A. M. Fuller, M. A. Lebedev, D. A. Turner, M. A. L. Nicolelis

Abstract

Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
Brazil 3 3%
France 3 3%
Canada 1 <1%
Netherlands 1 <1%
Austria 1 <1%
Belgium 1 <1%
China 1 <1%
Spain 1 <1%
Other 2 2%
Unknown 84 82%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 27%
Student > Ph. D. Student 19 19%
Student > Master 9 9%
Professor 8 8%
Student > Doctoral Student 6 6%
Other 23 23%
Unknown 9 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 25%
Medicine and Dentistry 24 24%
Neuroscience 17 17%
Engineering 9 9%
Psychology 8 8%
Other 6 6%
Unknown 12 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2012.
All research outputs
#3,460,241
of 4,889,971 outputs
Outputs from Journal of Neuroscience
#8,731
of 10,264 outputs
Outputs of similar age
#50,094
of 76,866 outputs
Outputs of similar age from Journal of Neuroscience
#245
of 295 outputs
Altmetric has tracked 4,889,971 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,264 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 295 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.