Title |
Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation
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Published in |
BMC Genomics, June 2012
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DOI | 10.1186/1471-2164-13-277 |
Pubmed ID | |
Authors |
Elma MJ Salentijn, D Cristina Mitea, Svetlana V Goryunova, Ingrid M van der Meer, Ismael Padioleau, Luud JWJ Gilissen, Frits Koning, Marinus JM Smulders |
Abstract |
Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-cell epitopes (9-mer peptides; CD epitopes) that mediate the stimulation of HLA-DQ2/8 restricted T-cells. Next to the thoroughly characterized major T-cell epitopes derived from the α-gliadin fraction of gluten, γ-gliadin peptides are also known to stimulate T-cells of celiac disease patients. To pinpoint CD-toxic γ-gliadins in hexaploid bread wheat, we examined the variation of T-cell epitopes involved in CD in γ-gliadin transcripts of developing bread wheat grains. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 5% |
Italy | 1 | 1% |
Germany | 1 | 1% |
Canada | 1 | 1% |
Paraguay | 1 | 1% |
Unknown | 67 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 24 | 32% |
Student > Ph. D. Student | 10 | 13% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Professor > Associate Professor | 5 | 7% |
Other | 12 | 16% |
Unknown | 11 | 15% |
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Nursing and Health Professions | 3 | 4% |
Other | 8 | 11% |
Unknown | 11 | 15% |