Title |
Plant G-Proteins Come of Age: Breaking the Bond with Animal Models
|
---|---|
Published in |
Frontiers in Chemistry, May 2016
|
DOI | 10.3389/fchem.2016.00024 |
Pubmed ID | |
Authors |
Yuri Trusov, José R. Botella |
Abstract |
G-proteins are universal signal transducers mediating many cellular responses. Plant G-protein signaling has been modeled on the well-established animal paradigm but accumulated experimental evidence indicates that G-protein-dependent signaling in plants has taken a very different evolutionary path. Here we review the differences between plant and animal G-proteins reported over past two decades. Most importantly, while in animal systems the G-protein signaling cycle is activated by seven transmembrane-spanning G-protein coupled receptors, the existence of these type of receptors in plants is highly controversial. Instead plant G-proteins have been proven to be functionally associated with atypical receptors such as the Arabidopsis RGS1 and a number of receptor-like kinases. We propose that, instead of the GTP/GDP cycle used in animals, plant G-proteins are activated/de-activated by phosphorylation/de-phosphorylation. We discuss the need of a fresh new look at these signaling molecules and provide a hypothetical model that departs from the accepted animal paradigm. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 57% |
Science communicators (journalists, bloggers, editors) | 2 | 29% |
Members of the public | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 112 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 19% |
Researcher | 14 | 13% |
Student > Master | 13 | 12% |
Student > Bachelor | 11 | 10% |
Professor | 6 | 5% |
Other | 13 | 12% |
Unknown | 34 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 43 | 38% |
Biochemistry, Genetics and Molecular Biology | 23 | 21% |
Medicine and Dentistry | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
Nursing and Health Professions | 1 | <1% |
Other | 3 | 3% |
Unknown | 39 | 35% |