Title |
Cancer stem cell metabolism
|
---|---|
Published in |
Breast Cancer Research, May 2016
|
DOI | 10.1186/s13058-016-0712-6 |
Pubmed ID | |
Authors |
Maria Peiris-Pagès, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Federica Sotgia, Michael P. Lisanti |
Abstract |
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 9% |
United States | 1 | 9% |
Italy | 1 | 9% |
Unknown | 8 | 73% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 55% |
Science communicators (journalists, bloggers, editors) | 3 | 27% |
Scientists | 1 | 9% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
United States | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 452 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 78 | 17% |
Student > Bachelor | 65 | 14% |
Researcher | 62 | 14% |
Student > Master | 51 | 11% |
Student > Doctoral Student | 34 | 7% |
Other | 47 | 10% |
Unknown | 118 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 133 | 29% |
Agricultural and Biological Sciences | 64 | 14% |
Medicine and Dentistry | 54 | 12% |
Chemistry | 17 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 4% |
Other | 39 | 9% |
Unknown | 132 | 29% |